CHOP
Cyclophophamide 750 mg/m2 iv d1
Doxorubicin 50 mg/m2 iv d1
Vincristine 1.4 mg/m2 ( max 2 mg ) iv d1
Prednisone 100 mg po qd d1-5
Q3w x 6-8 cycles
R-CHOP
Rituximab 375 mg/m2 iv d1
Cyclophophamide 750 mg/m2 iv d1
Doxorubicin 50 mg/m2 iv d1
Vincristine 1.4 mg/m2 ( max 2 mg ) iv d1
Prednisone 100 mg po qd d1-5
Q3w x 6-8 cycles
R-CHOP-14
Rituximab 375 mg/m2 iv d1
Cyclophophamide 750 mg/m2 iv d1
Doxorubicin 50 mg/m2 iv d1
Vincristine 1.4 mg/m2 ( max 2 mg ) iv d1
Prednisone 100 mg po qd d1-5
Q2w x 6 cycles
CEPP
non-anthracycline-containing regimen)
Cyclophosphamide 600 mg/m2 iv d1 and 8
Etoposide (VP-16) 70 mg/m2/d iv d1-3
Procarbazine 60 mg/m2/d po d1-10
Prednisone 60 mg/m2/d po d1-10
Q4w x 6 cycles
ICE
regimen 1
Ifosfamide 1000 mg/m2/d iv over 1 h d1-2 (hours 0 and 1)
Etoposide (VP-16) 150 mg/m2/d iv over 11 hrs after ifosfamide d1-2 (hours 1-11)
Carboplatin 200 mg/m2/d iv over 1 h after etoposide d1-2 (hours 11-12)
Etoposide (VP-16) 150 mg/m2/d iv over 11 hrs after carboplatin d1-2 (hours 12-24)
Mesna 333 mg/m2 iv 30 minutes before ifosfamide, repeat 4 and 8 hrs after ifosfamide
Q4w x 2 cycles
regimen 2
Ifosfamide 5000 mg/m2 mixed with Mesna 5000 mg/m2 iv over 24 hrs d2
Carboplatin AUC 5 (max 800mg) iv d2
Etoposide (VP-16) 100 mg/m2/d iv d1-3
Filgrastim 5 ug/kg sc qd d5-12
Q2w x 3 cycles
RICE
Rituximab (Rituxan) 375 mg/m2 iv d1 q2w x 3 cycles
ICE regimen 2 as above
ESHAP
Etoposide (VP-16) 40 mg/m2/d iv over 1 hr d1-4
Methylprednisolone 500 mg/d iv over 15 min d1-5
Cisplatin (CDDP) 25 mg/m2/d civi d1-4
Cytarabine (Ara-C) 2000 mg/m2 iv over 2 hr d5
Q3-4w x 6-8 cycles
EPOCH
Etoposide (VP-16) 50 mg/m2/d civi d1-4
Prednisone 60 mg/m2/d po d1-5
Vincristine 0.4 mg/m2/d civi d1-4
Doxorubicin 10 mg/m2/d civi d1-4
Cyclophosphamide 750 mg/m2 iv over 15 min d5
Bactrim DS 1 tablet po bid tiw
Filgrastim 5 mcg/kg sc qd beginining on d6 till ANC > 10,000/uL
Q3w x 6-8 cycles
Dose-adjusted EPOCH
Etoposide (VP-16) 50 mg/m2/d civi d1-4
Prednisone 60 mg/m2/d po d1-5
Vincristine 0.4 mg/m2/d civi d1-4
Doxorubicin 10 mg/m2/d civi d1-4
Cyclophosphamide 750 mg/m2 iv over 15 min d5
Bactrim DS 1 tablet po bid tiw
Filgrastim 5 mcg/kg sc qd beginining on d6 till ANC > 5,000/uL
Q3w x 6-8 cycles
Dose-adjustment paradigm based on twice weekly CBC (dose adjustment above starting doses apply to Etoposide (VP-16), Doxorubicin and Cyclophosphamide . dose adjustment below starting dose apply to Cyclophosphamide only) :
If nadir ANC > 500/uL, 20% increase in Etoposide (VP-16), Doxorubicin (Adriamycin) and Cyclophosphamide above last cycle
If nadir ANC < 500/uL on 1 or 2 measurements, same doses as last cycle
If nadir ANC < 500/uL on at least 3 measurements, or nadir platelet < 25,000/uL on 1 measurement, 20% decrease in Etoposide (VP-16), Doxorubicin and Cyclophosphamide below last cycle
MINE
Mesna 1330 mg/m2/d iv over 1 hr with ifosfamide d1-3, then 500 mg po 4 hrs after ifosfamide d1-3
Ifosfamide 1330 mg/m2/d iv over 1 hr d1-3
Mitoxantrone (Novantrone) 8 mg/m2 iv d1
Etoposide (VP-16) 65 mg/m2/d iv over 1 hr d1-3
Q3w
DHAP
Dexamethasone 40 mg po qd d1-4
Cisplatin (CDDP) 100 mg/m2 iv over 24 hrs d1
Cytarabine (Ara-C) 2000 mg/m2 iv q12 hrs for 2 doses d2
Q3-4w
R-GemOx
Rituximab 375 mg/m2 iv d1
Gemcitabine 1000 mg/m2 iv d2
Oxaliplatin 100 mg/m2 iv over 2 hrs d2
Q2-3w x 8 cycles